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Hyperbaric oxygen in the treatment of refractory hemorrhagic cystitis

Case report

A J Hughes(1), A P Schwarer1, and I L Millar(2)

1 Bone Marrow Transplant Programme, Alfred Hospital, Melbourne, Australia

2 Hyperbaric Service, Alfred Hospital, Melbourne, Australia


Hemorrhagic cystitis is a common and often debilitating complication of chemotherapy for which treatment is frequently unsatisfactory. With over 80 cases reported of radiation-induced cystitis treated successfully with hyperbaric oxygen, attention is now turning to the treatment of chemotherapeutic agent-induced cystitis. We report a case of hemorrhagic cystitis occurring after autologous peripheral blood stem cell transplantation for multiple myeloma. The patient had received cyclophosphamide and busulfan and had BK and adenoviruria. The hemorrhage was refractory to multiple conventional treatments but resolved after a course of hyperbaric oxygen.

Reprinted with Permission